Recently a new treatment of vitiligo has been shown as effective which is named as 208-nm XeCl excimer laser. Researchers assessed in this study three routines of treatment to conclude whether total number of sessions or frequency is more important and useful for white spots especially vitiligo disease. Fourteen patients with three different vitiligo patches on the same part of the body were given once weekly, two time in a week, or three times in a week laser treatment for the twelve weeks. 15mJ per cm2 was the initial dose which is less than the dose of minimal erythematous. Depending upon the level of erythema, successive doses were increased more and more in the last session. Full course of 12 weeks was given to the seven patients and treatment of minimum 6 weeks was given to the 13 patients.

Laser produced repigmentation is linked with the total number of medications but not directly with the frequency. At the end of 3rd week, patients showed repigmentation up to 15% in the patches that were given the treatment three times weekly. But in the end of 12th week the percentage of the repigmented patches was almost close in all the three groups i.e. 46%, 62% and 69% in the patches treated with once weekly, twice weekly and three times weekly. All the three treatments led to an important initiation of repigmentation as compared to the patches which were not treated. Repigmentation continued during the whole twelve months record in most patches cases. Ratio of side effect was mostly in that group which was given treatments three times a week including, moderate to severe erythema, stinging and burning, circumcised blisters and edema had required to skip or reduce the next dose.

This treatment is not surprising like other light sensitive conditions and UV based treatments. Study at a vast level with the courses of longer treatment and record will be very much necessary to decide the effectiveness of this particular method of therapy for vitiligo and to find out the suitable number of treatments as well.